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  • Writer's pictureJoan Rothchild Hardin

A Systems Biologist Explains How Our Immune Systems Work

Dr Shiva Ayyadurai holds four degrees from MIT, including a PhD in Biological Engineering specializing in Systems Biology. His doctoral thesis focused on modeling the whole cell by integrating molecular pathway models. In 2007, he was awarded a Fulbright US Student Program grant to study the integration of Siddha, a system of traditional medicine developed in South India, with modern systems biology.

Dr Ayyadurai founded CytoSolve, Inc. in 2011 to fulfill his life-long mission to promote human health and well-being by developing medicines and protocols, and integrating ancient and modern science with Eastern and Western traditional medicine.

CytoSolve provides the world’s first computational systems biology platform for scalable integration of molecular pathway models to enable predictive and quantitative understanding of complex biomolecular processes and diseases to determine risk, toxicity, and efficacy UPFRONT in the product development process. CytoSolve’s technology platform is enabling innovative and visionary manufacturers to develop and deliver products to end-consumers that truly advance health and well-being, faster, cheaper, and safer.” (CytoSolve, Inc, 2011-2020)



In the video below, Dr Ayyadurai presents a fuller and updated explanation of the parts of the immune system and how they work in concert to protect us from illness, including the Coronavirus-19.

These parts include the Innate Immune System, the Interferon System, the Gut Microbiome, the Neural System, and the Adaptive Immune System.


In the video, Dr Ayyadurai also explains why vaccines are not a healthy solution for preventing diseases. Vaccines stimulate the production of antibodies for a particular disease but also short circuit the complex balance among the various parts of the total immune system. These artificially produced antibodies create a constant low-level inflammatory response in the body which, over time, creates autoimmune diseases and conditions.

This is important information on a downside of vaccines:

Unlike antibodies the body produces when you’ve had and recovered from a disease, vaccines artificially overstimulate the production of antibodies, creating a chronic low-level inflammatory response in the body, eventually causing autoimmune diseases and conditions.


The following are excerpts from an article by Dr Josh Axe about how a leaky gut produces chronic inflammation in the body, eventually producing most of the diseases we get.

“As more Americans are affected by poor diet choices, chronic stress, toxic overload and bacterial imbalance, it appears that the prevalence of leaky gut has reached epidemic proportions. The medical profession is just now agreeing this condition may even exist, which is especially shocking to me because “intestinal permeability” (another name for leaky gut) has been discussed in the medical literature for over 100 years!

“Why should leaky gut syndrome concern you? Recently leaky gut has been called a “danger signal for autoimmune disease.” (1) If you’re wondering if you may be experiencing leaky gut, the first thing to do is access your symptoms. Keep in mind that it’s very common for people on a Standard American Diet to struggle with poor gut function and high levels of inflammation — but just because digestive issues and autoimmune conditions are common doesn’t make them “normal”! …. “Here’s how a report published in the journal Frontiers in Immunology describes the pathology of leaky gut: (2)

The intestinal epithelial lining, together with factors secreted from it, forms a barrier that separates the host from the environment. In pathologic conditions, the permeability of the epithelial lining may be compromised allowing the passage of toxins, antigens, and bacteria in the lumen to enter the bloodstream creating a ‘leaky gut.’

“When you have leaky gut, certain tiny particles that should never be able to enter your bloodstream start to make their way through. There’s also commonly abnormalities in the gut stemming from antimicrobial molecules, immunoglobulins and cytokine activities. This presents a major problem, as the vast majority of your immune system is found inside the gut.

“The result? A disruption of acute inflammation, and sometimes autoimmune reactions. A normal part of your immune response that serves to fight infections and diseases winds up over-performing, leading to chronic inflammation, which is at the root of most diseases.”

– Axe, 2018 See also INCREASED GUT PERMEABILITY – CAUSES & CONSEQUENCES to read more about the serious consequences of chronic low-level inflammation in the body. (Hardin, 2015)


Ayyadurai, S. (1/2/2020). MIT PhD Dr. Shiva Ayyadurai Explains the Reality of the Modern Immune System. Video. See:

CytoSolve, Inc. (2011-2020). See: Hardin, J.R. (5/10/2015). INCREASED GUT PERMEABILITY – CAUSES & CONSEQUENCES. See:

© Copyright 2020. Joan Rothchild Hardin. All Rights Reserved.

DISCLAIMER:  Nothing on this site or blog is intended to provide medical advice, diagnosis or treatment.

Comments submitted prior to 8/25/2021

While it might be true that “Unlike antibodies the body produces when you’ve had and recovered from a disease, vaccines artificially over stimulate the production of antibodies, creating a chronic low-level inflammatory response in the body, eventually causing autoimmune diseases and conditions.” … this assumes that one would survive the disease (or survive it with less ill effects than said possible chronic inflammation … If the choice is between vaccine (and life) or full on illness (and death to self or vulnerable others), I would think that many might choose the vaccine. For example, while polio vaccines may come with risks of chronic inflammation, being dead from polio, while preventing ‘chronic inflammation’ … prevents ‘chronic’ life continuing, too. … So, like many other things, it is a risk-benefit assessment. Similarly, I know parents who lose infants to Whooping Cough, when the newborns got infected from adults who were unvaccinated. I know children who were badly disabled following being infected with measles, mumps, and/or rubella (in the mother during pregnancy). I know people who died from hepatitis. My mother lost friends to diphtheria as a child, before the vaccines were available. So, while vaccines might well have some risks, for sure, many of the illnesses they are developed to vaccinate against have very serious risks, often far worse risks. So … I’d say that we can look down at vaccines from the privileged places of having the option to take them and having far fewer children who are dead before the age of 5 because they get ill with diseases we now vaccinate against and therefore rarely see. FWIW.

Na’ama Yehuda

In reply to Na'ama Yehuda.Na’ama,

I agree the entire vaccines issue is one of risk/benefit. I’m concerned however that whatever vaccine(s) will be developed in response to this Coronavirus-19 pandemic will go to market well before being adequately tested for both short- and long-term safety. So many people, including elderly folks, people with an array of autoimmune diseases & conditions, and people who’ve already had COVID-19, now seem to believe without question that a vaccine is soon going to be the answer to the pandemic – that as soon as one becomes available it’s

going to make it safe to remove or seriously reduce preventative measures now in place.

I’m of the opinion that people need to be fully informed about all medical treatments so they can make their intelligent decisions about what goes into their bodies, rather than having their doctors, governments or health organizations like the CDC & WHO making those decisions for them. Perhaps there will be other effective ways to protect ourselves against Coronavirus-19 & other future deadly viral pandemics: antibody treatments, a way to have our immune systems kill off the virus or some other methods researchers are currently investigating.

Joan Hardin


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